smiles zinc_id prot_id files.db2 substance.inchikey net_charge ph_mod_fk substance.mwt substance.logp purchasable reactive features tranche_name O=C1c2ccccc2C(=O)N1CCCC[NH+]1CCN(c2ccc([N+](=O)[O-])cc2)CC1 ZINC000007498866 132324727 /nfs/dbraw/zinc/32/47/27/132324727.db2.gz FPHNZJMXBULNRR-UHFFFAOYSA-N 1 0 408.458 2.793 40 5 HFBBRO Cc1ccc(C(=O)NC(=S)Nc2ccccc2N2CC[NH+](C)CC2)cc1[N+](=O)[O-] ZINC000033779673 568698639 /nfs/dbraw/zinc/69/86/39/568698639.db2.gz KRLRRBAHKXSZPI-UHFFFAOYSA-N 1 0 413.503 2.782 40 5 HFBBRO Cc1c(Nc2cc(-c3cccnc3)nc(NCCC[NH+](C)C)n2)cccc1[N+](=O)[O-] ZINC000329061283 569424917 /nfs/dbraw/zinc/42/49/17/569424917.db2.gz WQILTXLGBZPXFW-UHFFFAOYSA-N 1 0 407.478 2.706 40 5 HFBBRO O=C(CN1CCC(NC(=O)Nc2ccc(F)cc2)CC1)Nc1ccccc1[N+](=O)[O-] ZINC000004908990 559199423 /nfs/dbraw/zinc/19/94/23/559199423.db2.gz IXWJZZPUOMRNRV-UHFFFAOYSA-N 1 0 415.425 2.959 40 5 HFBBRO CC[NH+]1CCN(c2ccc(NC(=S)NC(=O)c3ccccc3[N+](=O)[O-])cc2)CC1 ZINC000017089588 569273593 /nfs/dbraw/zinc/27/35/93/569273593.db2.gz WZXYOHGNFKVHRG-UHFFFAOYSA-N 1 0 413.503 2.864 40 5 HFBBRO C[NH+](C)CCCNc1nc(Nc2ccc(F)c([N+](=O)[O-])c2)cc(-c2cccnc2)n1 ZINC000328962101 569422794 /nfs/dbraw/zinc/42/27/94/569422794.db2.gz BHJFRRPSCIHPGK-UHFFFAOYSA-N 1 0 411.441 2.537 40 5 HFBBRO O=C(Nc1ccc(N2CC[NH2+]CC2)c([N+](=O)[O-])c1)c1cc([N+](=O)[O-])ccc1Cl ZINC000020154266 568590666 /nfs/dbraw/zinc/59/06/66/568590666.db2.gz LLCQTFLTQTUJPP-UHFFFAOYSA-N 1 0 405.798 2.818 40 5 HFBBRO C[NH+](C)CCCNc1nc(Nc2ccc(F)cc2[N+](=O)[O-])cc(-c2ccncc2)n1 ZINC000328988363 569423287 /nfs/dbraw/zinc/42/32/87/569423287.db2.gz IGFGWAHKTDESMW-UHFFFAOYSA-N 1 0 411.441 2.537 40 5 HFBBRO COc1ccc([N+](=O)[O-])cc1NC(=O)CC[NH+]1CCN(c2ccc(F)cc2)CC1 ZINC000020258750 568596356 /nfs/dbraw/zinc/59/63/56/568596356.db2.gz MCPUSKQRDFWHCH-UHFFFAOYSA-N 1 0 402.426 2.893 40 5 HFBBRO COC(=O)c1ccc(N2CC[NH+](C)CC2)c(NC(=O)c2ccc(C)c([N+](=O)[O-])c2)c1 ZINC000021595828 568722415 /nfs/dbraw/zinc/72/24/15/568722415.db2.gz BJRAANYUTSOAJO-UHFFFAOYSA-N 1 0 412.446 2.694 40 5 HFBBRO C[NH+]1CCC(Oc2ccc(CNS(=O)(=O)c3ccccc3[N+](=O)[O-])cc2)CC1 ZINC000216941343 568845155 /nfs/dbraw/zinc/84/51/55/568845155.db2.gz UXCKQCIVVKMAAR-UHFFFAOYSA-N 1 0 405.476 2.546 40 5 HFBBRO O=C(c1ccc([N+](=O)[O-])cc1)N1CCO[C@]2(CCCC[C@@H]2[NH2+]Cc2cccnc2)C1 ZINC000306133261 568901439 /nfs/dbraw/zinc/90/14/39/568901439.db2.gz MGUIUDHIGPYTFL-RBBKRZOGSA-N 1 0 410.474 2.933 40 5 HFBBRO O=C(Nc1ccc(N2CC[NH2+]CC2)c([N+](=O)[O-])c1)c1ccc(Cl)c([N+](=O)[O-])c1 ZINC000020154270 568590494 /nfs/dbraw/zinc/59/04/94/568590494.db2.gz NDURSMZEFHUACZ-UHFFFAOYSA-N 1 0 405.798 2.818 40 5 HFBBRO C[N@H+]1[C@@H]2CC[C@H]1CC(NC(=O)c1ccc(Cn3cc(Cl)c([N+](=O)[O-])n3)cc1)C2 ZINC000002809555 568810937 /nfs/dbraw/zinc/81/09/37/568810937.db2.gz YPXFTSYWWSEUIR-MQVJKMGUSA-N 1 0 403.870 2.848 40 5 HFBBRO C[NH+]1CCN(CCCNC(=O)/C(=C/c2cccc([N+](=O)[O-])c2)c2ccccc2)CC1 ZINC000013668824 558853085 /nfs/dbraw/zinc/85/30/85/558853085.db2.gz OHSNESOGNLOSMR-RELWKKBWSA-N 1 0 408.502 2.889 40 5 HFBBRO CCOC(=O)C1=C(C[NH+]2C[C@@H](C)C[C@H](C)C2)NC(=O)N[C@@H]1c1cccc([N+](=O)[O-])c1 ZINC000055226457 569394558 /nfs/dbraw/zinc/39/45/58/569394558.db2.gz LJLIJZXNGHHLPB-CKFHNAJUSA-N 1 0 416.478 2.744 40 5 HFBBRO CC[NH+](CC)CCN(CC(=O)NC1CCCCC1)C(=O)c1ccc([N+](=O)[O-])cc1 ZINC000005453244 560589891 /nfs/dbraw/zinc/58/98/91/560589891.db2.gz SPPTZIIONCJRCO-UHFFFAOYSA-N 1 0 404.511 2.828 40 5 HFBBRO O=C(c1ccc([N+](=O)[O-])cc1)N1CCO[C@]2(CCCC[C@H]2[NH2+]Cc2cccnc2)C1 ZINC000306133259 568901421 /nfs/dbraw/zinc/90/14/21/568901421.db2.gz MGUIUDHIGPYTFL-IFMALSPDSA-N 1 0 410.474 2.933 40 5 HFBBRO CCOc1cc(C[NH2+]CCNc2ccc([N+](=O)[O-])cc2)cc(Cl)c1OCC(N)=O ZINC000006870219 569157739 /nfs/dbraw/zinc/15/77/39/569157739.db2.gz DQRQFNDFAVSTPN-UHFFFAOYSA-N 1 0 422.869 2.713 40 5 HFBBRO C[NH+](C)CCCNc1nc(NCc2cccc([N+](=O)[O-])c2)cc(-c2ccccc2)n1 ZINC000328973147 569422903 /nfs/dbraw/zinc/42/29/03/569422903.db2.gz DZJOVYLOAZOEIE-UHFFFAOYSA-N 1 0 406.490 2.871 40 5 HFBBRO C[NH2+]CCn1c(=O)c2cc(OC)c(OC)cc2c2cnc3cc4c(cc3c21)OCO4 ZINC000006718458 557716962 /nfs/dbraw/zinc/71/69/62/557716962.db2.gz BAORCAMWLWRZQG-UHFFFAOYSA-N 1 0 407.426 2.668 40 5 HFBBRO C[NH+](C)CCCNc1nc(Nc2ccc(F)cc2[N+](=O)[O-])cc(-c2ccccn2)n1 ZINC000328979589 569423007 /nfs/dbraw/zinc/42/30/07/569423007.db2.gz GGVKHZWQUDFITD-UHFFFAOYSA-N 1 0 411.441 2.537 40 5 HFBBRO C[NH+]1CCN(c2cc3[nH]c(=O)[nH]c3cc2NC(=O)C=Cc2ccc([N+](=O)[O-])cc2)CC1 ZINC000408533093 559216877 /nfs/dbraw/zinc/21/68/77/559216877.db2.gz OCAIJMWBUVSETB-QPJJXVBHSA-N 1 0 422.445 2.580 40 5 HFBBRO COc1ccc(Nc2cc(-c3ccccc3)nc(NCC[NH+](C)C)n2)c([N+](=O)[O-])c1 ZINC000328983650 569423036 /nfs/dbraw/zinc/42/30/36/569423036.db2.gz HHUMAKCCWALATJ-UHFFFAOYSA-N 1 0 408.462 2.621 40 5 HFBBRO C[NH+]1CCC(Oc2ccc(CNS(=O)(=O)c3cccc([N+](=O)[O-])c3)cc2)CC1 ZINC000216941968 568847555 /nfs/dbraw/zinc/84/75/55/568847555.db2.gz MNDHUFVOTMQHFQ-UHFFFAOYSA-N 1 0 405.476 2.546 40 5 HFBBRO O=C(c1ccc([N+](=O)[O-])cc1)N1CCO[C@@]2(CCCC[C@@H]2[NH2+]Cc2cccnc2)C1 ZINC000306133262 568901291 /nfs/dbraw/zinc/90/12/91/568901291.db2.gz MGUIUDHIGPYTFL-UNMCSNQZSA-N 1 0 410.474 2.933 40 5 HFBBRO O=C1c2cccc3c(N4CC[NH2+]CC4)ccc(c23)C(=O)N1c1cccc([N+](=O)[O-])c1 ZINC000016399905 569041151 /nfs/dbraw/zinc/04/11/51/569041151.db2.gz ZPCSVUGDRNHQKD-UHFFFAOYSA-N 1 0 402.410 2.958 40 5 HFBBRO [NH3+]CCCC[C@@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1 ZINC000005603328 557664795 /nfs/dbraw/zinc/66/47/95/557664795.db2.gz FKFJWYPXPIUVGU-GOSISDBHSA-N 1 0 400.435 2.957 40 5 HFBBRO Cc1cc(OCC(=O)Nc2ccc(N3CC[NH2+]CC3)c([N+](=O)[O-])c2)ccc1Cl ZINC000020154337 568590492 /nfs/dbraw/zinc/59/04/92/568590492.db2.gz ABFDIMWYHKPNEO-UHFFFAOYSA-N 1 0 404.854 2.984 40 5 HFBBRO COc1cccc(-n2ccc3nc4ccn(CCC[NH+](C)C)c(=O)c4cc3c2=O)c1 ZINC000038829033 558816117 /nfs/dbraw/zinc/81/61/17/558816117.db2.gz FZELXOOYFIHJHQ-UHFFFAOYSA-N 1 0 404.470 2.661 40 5 HFBBRO CCOC(=O)C1=C(C[NH+]2C[C@@H](C)C[C@H](C)C2)NC(=O)N[C@H]1c1cccc([N+](=O)[O-])c1 ZINC000055226462 569394629 /nfs/dbraw/zinc/39/46/29/569394629.db2.gz LJLIJZXNGHHLPB-NJSLBKSFSA-N 1 0 416.478 2.744 40 5 HFBBRO C[NH+](C)CCCNc1nc(NCc2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 ZINC000329033365 569423799 /nfs/dbraw/zinc/42/37/99/569423799.db2.gz QTWPBODPFWQNSW-UHFFFAOYSA-N 1 0 406.490 2.871 40 5 HFBBRO COC(=O)c1ccc(N2CC[NH+](C)CC2)c(NC(=O)/C=C/c2cccc([N+](=O)[O-])c2)c1 ZINC000057314151 568826393 /nfs/dbraw/zinc/82/63/93/568826393.db2.gz IGAPDHPMFSTLGJ-RMKNXTFCSA-N 1 0 424.457 2.785 40 5 HFBBRO C[NH+](C)CCCNc1nc(NCc2ccccc2[N+](=O)[O-])cc(-c2ccccc2)n1 ZINC000328955358 569422805 /nfs/dbraw/zinc/42/28/05/569422805.db2.gz ACJULIFPQZYYPV-UHFFFAOYSA-N 1 0 406.490 2.871 40 5 HFBBRO CC1(C)NC(=[NH2+])NC(=N)N1c1cccc(OCCCOc2cccc([N+](=O)[O-])c2)c1 ZINC000001703366 534962081 /nfs/dbraw/zinc/96/20/81/534962081.db2.gz RWKJNXZSLJHMOW-UHFFFAOYSA-N 1 0 412.450 2.628 40 5 HFBBRO C[NH+](C)CCCNc1nc(Nc2ccc(F)cc2[N+](=O)[O-])cc(-c2cccnc2)n1 ZINC000328994481 569423272 /nfs/dbraw/zinc/42/32/72/569423272.db2.gz JEMAFHVVGHEPPV-UHFFFAOYSA-N 1 0 411.441 2.537 40 5 HFBBRO C[NH+](C)CCCn1ccc2nc3ccn(CCc4ccccc4)c(=O)c3cc2c1=O ZINC000040398827 524057936 /nfs/dbraw/zinc/05/79/36/524057936.db2.gz DHPXASDHEQTFOA-UHFFFAOYSA-N 1 0 402.498 2.906 40 5 HFBBRO Cc1ccc(C(=O)NC(=S)Nc2ccc(N3CC[NH+](C)CC3)cc2)cc1[N+](=O)[O-] ZINC000017089585 569273484 /nfs/dbraw/zinc/27/34/84/569273484.db2.gz LHLFGNFPZCGIAF-UHFFFAOYSA-N 1 0 413.503 2.782 40 5 HFBBRO Cc1c(Nc2cc(-c3ccncc3)nc(NCCC[NH+](C)C)n2)cccc1[N+](=O)[O-] ZINC000328988284 569423294 /nfs/dbraw/zinc/42/32/94/569423294.db2.gz IFULDPANFDTJIP-UHFFFAOYSA-N 1 0 407.478 2.706 40 5 HFBBRO C[NH+](C)CCNc1nc(Nc2cc(Cl)ccc2[N+](=O)[O-])cc(-c2ccncc2)n1 ZINC000328990334 569423322 /nfs/dbraw/zinc/42/33/22/569423322.db2.gz INRKNZSVHMWJPD-UHFFFAOYSA-N 1 0 413.869 2.661 40 5 HFBBRO Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)NCc1ccc(OC2CC[NH+](C)CC2)cc1 ZINC000216947107 568847702 /nfs/dbraw/zinc/84/77/02/568847702.db2.gz QFYFEQLXGNRDKF-UHFFFAOYSA-N 1 0 419.503 2.855 40 5 HFBBRO Cc1c(Nc2cc(-c3ccccn3)nc(NCCC[NH+](C)C)n2)cccc1[N+](=O)[O-] ZINC000329025262 569423787 /nfs/dbraw/zinc/42/37/87/569423787.db2.gz PFAUCKRGHSBDTO-UHFFFAOYSA-N 1 0 407.478 2.706 40 5 HFBBRO CC(=O)Oc1cn(CCC[NH+]2CCOCC2)c2nc(C)n3c4ccccc4nc3c12 ZINC000020403659 558359904 /nfs/dbraw/zinc/35/99/04/558359904.db2.gz HTICWFDELSKNCX-UHFFFAOYSA-N 1 0 407.474 2.793 40 5 HFBBRO Cc1c(C(=O)NC(=S)Nc2ccccc2N2CC[NH+](C)CC2)cccc1[N+](=O)[O-] ZINC000107586772 569352673 /nfs/dbraw/zinc/35/26/73/569352673.db2.gz MRKREVRJOWXAJP-UHFFFAOYSA-N 1 0 413.503 2.782 40 5 HFBBRO O=[N+]([O-])c1ccc(CN2C[C@H](O)C[C@H]2c2nc(-c3cccc([N+](=O)[O-])c3)no2)cc1 ZINC000015674853 291230124 /nfs/dbraw/zinc/23/01/24/291230124.db2.gz XZCHWTLSQVOXIB-SJORKVTESA-N 1 0 411.374 2.861 40 5 biogenic,in-vitro HFBBRO COc1ccc(-n2ccc3nc4ccn(CCC[NH+](C)C)c(=O)c4cc3c2=O)cc1 ZINC000038829031 558816079 /nfs/dbraw/zinc/81/60/79/558816079.db2.gz LZXCKBXUIGDQDT-UHFFFAOYSA-N 1 0 404.470 2.661 40 5 HFBBRO [NH3+]CCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1 ZINC000005603321 560628912 /nfs/dbraw/zinc/62/89/12/560628912.db2.gz FKFJWYPXPIUVGU-SFHVURJKSA-N 1 0 400.435 2.957 40 5 HFBBRO O=C(c1ccc([N+](=O)[O-])cc1)N1CCO[C@@]2(CCCC[C@H]2[NH2+]Cc2cccnc2)C1 ZINC000306133260 568901326 /nfs/dbraw/zinc/90/13/26/568901326.db2.gz MGUIUDHIGPYTFL-IRLDBZIGSA-N 1 0 410.474 2.933 40 5 HFBBRO C[NH+](C)CCCNc1nc(Nc2ccc(F)c([N+](=O)[O-])c2)cc(-c2ccccn2)n1 ZINC000329056718 569424836 /nfs/dbraw/zinc/42/48/36/569424836.db2.gz VTXASTWSUHRNHS-UHFFFAOYSA-N 1 0 411.441 2.537 40 5 HFBBRO Cc1ccc(OCCNc2cc(N3CC[NH+](CCO)CC3)ccc2[N+](=O)[O-])cc1C ZINC000019904369 569433224 /nfs/dbraw/zinc/43/32/24/569433224.db2.gz BVEFSTQVPQOIQV-UHFFFAOYSA-N 1 0 414.506 2.817 40 5 HFBBRO COc1ccc(Cn2ccc3nc4ccn(CCC[NH+](C)C)c(=O)c4cc3c2=O)cc1 ZINC000040398794 524262154 /nfs/dbraw/zinc/26/21/54/524262154.db2.gz XPRWTSPIIUSZNA-UHFFFAOYSA-N 1 0 418.497 2.720 40 5 HFBBRO C[NH+](C)CCNc1nc(Nc2cc(Cl)ccc2[N+](=O)[O-])cc(-c2ccccn2)n1 ZINC000328964589 569422860 /nfs/dbraw/zinc/42/28/60/569422860.db2.gz BWNOJVAIRFSMRO-UHFFFAOYSA-N 1 0 413.869 2.661 40 5 HFBBRO O=C(Nc1ccc(N2CC[NH2+]CC2)c([N+](=O)[O-])c1)c1ccc([N+](=O)[O-])cc1Cl ZINC000020154264 568590489 /nfs/dbraw/zinc/59/04/89/568590489.db2.gz NORQZLNXHKVRJK-UHFFFAOYSA-N 1 0 405.798 2.818 40 5 HFBBRO O=C(CSCc1ccc([N+](=O)[O-])cc1)NCc1cccc(CN2CCOCC2)c1 ZINC000224706708 569283979 /nfs/dbraw/zinc/28/39/79/569283979.db2.gz VNEKKBBDZHGUKG-UHFFFAOYSA-N 1 0 415.515 2.977 40 5 HFBBRO O=C(CN1CCC(NC(=O)NC2CCCCC2)CC1)Nc1cccc([N+](=O)[O-])c1 ZINC000004909049 559199396 /nfs/dbraw/zinc/19/93/96/559199396.db2.gz LVLMVHVRESQROP-UHFFFAOYSA-N 1 0 403.483 2.630 40 5 HFBBRO Cc1c(C(=O)NC(=S)Nc2ccc(N3CC[NH+](C)CC3)cc2)cccc1[N+](=O)[O-] ZINC000017089587 569273532 /nfs/dbraw/zinc/27/35/32/569273532.db2.gz MQOANARVJLFQRW-UHFFFAOYSA-N 1 0 413.503 2.782 40 5 HFBBRO C[NH+](C)CCCNc1nc(Nc2ccc(F)c([N+](=O)[O-])c2)cc(-c2ccncc2)n1 ZINC000329067996 569425019 /nfs/dbraw/zinc/42/50/19/569425019.db2.gz YLRJOUWYZFPRHW-UHFFFAOYSA-N 1 0 411.441 2.537 40 5 HFBBRO CC1(C)NC(=[NH2+])NC(=N)N1c1cccc(OCCCOc2ccc([N+](=O)[O-])cc2)c1 ZINC000001704131 534962596 /nfs/dbraw/zinc/96/25/96/534962596.db2.gz RIENOKZCFDAIQG-UHFFFAOYSA-N 1 0 412.450 2.628 40 5 HFBBRO Cc1cc(Cl)ccc1OCC(=O)Nc1ccc(N2CC[NH2+]CC2)c([N+](=O)[O-])c1 ZINC000020154338 568590401 /nfs/dbraw/zinc/59/04/01/568590401.db2.gz QUAWYROFZOCPQY-UHFFFAOYSA-N 1 0 404.854 2.984 40 5 HFBBRO CC[NH+]1CCN(c2ccc(NC(=S)NC(=O)c3cccc([N+](=O)[O-])c3)cc2)CC1 ZINC000017089589 569273585 /nfs/dbraw/zinc/27/35/85/569273585.db2.gz RQVYZPHQMAHCIS-UHFFFAOYSA-N 1 0 413.503 2.864 40 5 HFBBRO Cc1ccc(S(=O)(=O)NCc2ccc(OC3CC[NH+](C)CC3)cc2)cc1[N+](=O)[O-] ZINC000216941435 568845165 /nfs/dbraw/zinc/84/51/65/568845165.db2.gz SBJQJXSXFRONFS-UHFFFAOYSA-N 1 0 419.503 2.855 40 5 HFBBRO C[NH+](C)CCNc1nc(Nc2cc(Cl)ccc2[N+](=O)[O-])cc(C(F)(F)F)n1 ZINC000328973171 569422917 /nfs/dbraw/zinc/42/29/17/569422917.db2.gz DZUKTPCSRHILHU-UHFFFAOYSA-N 1 0 404.780 2.618 40 5 HFBBRO O=[N+]([O-])c1ccc(CN2C[C@H](O)C[C@H]2c2nc(-c3ccc4c(c3)OCO4)no2)cc1 ZINC000015674986 291230115 /nfs/dbraw/zinc/23/01/15/291230115.db2.gz XUADLQSFRMHWGF-CVEARBPZSA-N 1 0 410.386 2.681 40 5 biogenic,in-vitro HFBBRO C[NH+](C)CCNc1nc(Nc2cc(Cl)ccc2[N+](=O)[O-])cc(-c2cccnc2)n1 ZINC000328981969 569422996 /nfs/dbraw/zinc/42/29/96/569422996.db2.gz GXIMENFQGOYQAL-UHFFFAOYSA-N 1 0 413.869 2.661 40 5 HFBBRO COc1ccccc1-n1ccc2nc3ccn(CCC[NH+](C)C)c(=O)c3cc2c1=O ZINC000038829035 558816071 /nfs/dbraw/zinc/81/60/71/558816071.db2.gz KMIUJKKAHGYZOP-UHFFFAOYSA-N 1 0 404.470 2.661 40 5 HFBBRO COC(=O)c1ccc(N2CC[NH+](C)CC2)c(NC(=O)c2ccc([N+](=O)[O-])c(C)c2)c1 ZINC000408569989 559218616 /nfs/dbraw/zinc/21/86/16/559218616.db2.gz RIRNPNFJYMEMSO-UHFFFAOYSA-N 1 0 412.446 2.694 40 5 HFBBRO C[NH+]1CCC(Oc2ccc(CNS(=O)(=O)Cc3cccc([N+](=O)[O-])c3)cc2)CC1 ZINC000217029363 568855164 /nfs/dbraw/zinc/85/51/64/568855164.db2.gz MNLYQXBPAMUJTQ-UHFFFAOYSA-N 1 0 419.503 2.687 40 5 HFBBRO C[NH+]1CCC(Oc2ccc(CNS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cc2)CC1 ZINC000216942030 568847708 /nfs/dbraw/zinc/84/77/08/568847708.db2.gz CRLMPCMJNJSTOC-UHFFFAOYSA-N 1 0 405.476 2.546 40 5 HFBBRO